Tobramycin + dexamethasone

Hypersensitivity to tobramycin or dexamethasone. Viral infections of cornea and conjunctiva (e.g. epithelial herpes simplex keratitis [dendritic keratitis], vaccinia, varicella), mycobacterial eye infection, fungal diseases of ocular structure, untreated parasitic eye infection, untreated purulent eye infection, post-uncomplicated removal of foreign body.

Patients with hypersensitivity to other aminoglycoside antibiotics, known or suspected neuromuscular disorder (e.g. myasthenia gravis, Parkinson's disease), glaucoma, history of ocular herpes simplex, diabetes. Children. Pregnancy and lactation. Patient Counselling Wearing of contact lenses during treatment of eye infection or inflammation is not recommended. If the use of contact lenses is allowed by the physician, remove contact lenses before administration and reinsert after 15 minutes. This drug may cause temporary blurring of vision, if affected, do not drive or operate machinery. Monitoring Parameters Monitor intraocular pressure especially if used for >10 days and in patients with glaucoma; signs and symptoms of secondary infection. Examine the patient with the aid of magnification such as slit lamp biomicroscopy or fluorescein staining (if appropriate) before initial prescription and renewal of medication.

Significant: Hypersensitivity reactions (e.g. erythema, pruritus, urticaria, skin rash, anaphylaxis, anaphylactoid or bullous reactions); secondary ocular infection (e.g. fungal infection), ocular hypertension or glaucoma, optic nerve injury, visual defects in acuity and field of vision, posterior subcapsular cataracts formation (prolonged use); central serous chorioretinopathy; overgrowth of non-susceptible organisms including fungi (prolonged use); slow corneal wound healing; cornea or scleral perforations (in diseases which thin the cornea or sclera). Eye disorders: Eye pain, eye pruritus, ocular discomfort, conjunctival oedema, eye irritation, eye allergy, blurred vision, dry eye, ocular hyperaemia, mydriasis, increased lacrimation, foreign body sensation. Gastrointestinal disorders: Dysgeusia. Investigations: Increased intraocular pressure. Nervous system disorders: Headache, dizziness. Respiratory, thoracic and mediastinal disorders: Rhinorrhoea, laryngospasm.

May increase risk for toxicity with systemic aminoglycosides. Tobramycin: May be inactivated if used concomitantly with topical β-lactam antibiotic. Dexamethasone: May increase the potential for corneal healing problems with topical NSAIDs. May increase risk of adrenal suppression or Cushing's syndrome with CYP3A4 inhibitors (e.g. ritonavir and cobicistat).

Eye Antiseptics with Corticosteroids

C05AA09 - dexamethasone ; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.
H02AB02 - dexamethasone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.
D10AA03 - dexamethasone ; Belongs to the class of topical corticosteroids used in the treatment of acne.
S01BA01 - dexamethasone ; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.
S02BA06 - dexamethasone ; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear.
A01AC02 - dexamethasone ; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth.
D07XB05 - dexamethasone ; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases.
S01AA12 - tobramycin ; Belongs to the class of antibiotics. Used in the treatment of eye infections.
S03BA01 - dexamethasone ; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations.
D07AB19 - dexamethasone ; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.
S01CB01 - dexamethasone ; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.
R01AD03 - dexamethasone ; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.
J01GB01 - tobramycin ; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.